DTP3 TFA
CAS No.
DTP3 TFA ( —— )
Catalog No. M22336 CAS No.
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 (10 μM; 1-21 days) causes the potent and tumor-selective induction of JNK activation and apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 179 | Get Quote |
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10MG | 300 | Get Quote |
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25MG | 405 | Get Quote |
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50MG | 567 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameDTP3 TFA
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NoteResearch use only, not for human use.
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Brief DescriptionDTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 (10 μM; 1-21 days) causes the potent and tumor-selective induction of JNK activation and apoptosis.
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DescriptionDTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 (10 μM; 1-21 days) causes the potent and tumor-selective induction of JNK activation and apoptosis, as shown by the appearance of phosphorylated JNK, as early as 24 hours[2]. DTP3 TFA (s.c.; 14.5 mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, and virtually eradicates established subcutaneous myeloma xenografts in mice. DTP3 TFA (intravenous injection; 10 mg/kg/day) has t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorGADD45β/MKK7
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight639.62
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Molecular FormulaC28H36F3N7O7
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Purity>98% (HPLC)
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SolubilityH2O:100 mg/mL (156.34 mM; Need ultrasonic);DMSO:50 mg/mL (78.17 mM; Need ultrasonic)
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SMILESOc2ccc(C[C@@H](NC(C)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(N)=O)cc2.FC(F)(F)C(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tornatore L, et al. Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019 Apr 19;6:369-379.
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